… and testosterone signaling pathways in Sertoli cell proliferation… process, for example 5α-dihydrotestosterone
(DHT) regulates … cell cycle arrest by interacting with 17β-estradiol (E2) (106). …

… The cAMP/PKA signaling pathway participates in Sertoli cell differentiation, SSC self-renewal …
in immature rat SCs activates the caspase 9 mediated intrinsic apoptotic pathway [118]. …

… has been detected in Leydig cells, Sertoli cells and germ cells, notably in spermatogonia, …
is converted into 5α-dihydrotestosterone by 5α-reductase (SRD5A1), or into 17β-estradiol by …

… The immature Sertoli cell varies greatly from … 5α-dihydrotestosterone on Sertoli cell cholesterol
metabolism resembled those of insulin, but were less obvious. By contrast, 17β-estradiol (…

… by estrogen (A) and androgen (B) after 17β-estradiol (E2) (10 −9 M… These apoptotic bodies
are phagocytosed by Sertoli cells. … In addition, estrogen also activates signaling pathways via …

… androgen, or via binding of 5α-dihydrotestosterone, an active … In a comparable fashion,
17β-estradiol produced by … are mediated by alternative signaling pathways involving calcium (Ca+…

… 10% fetal calf serum and 5α-dihydrotestosterone (1 nM), sodium … 17β-estradiol was applied
at the apical side of the immature … in apoptosis of Sertoli cells and spermatocytes through …

… , regulation of ion transport and regulation of apoptosis in … the Sertoli cells after treatment
with estradiol. Following the development of such vacuoles in Sertoli cells, immature germ cells …

… , Sod2, Cat, and Gpx1), apoptosis-related genes (Bcl2 and Bax), … regulated NR3C4 expression
in Sertoli cells and immature … Leydig cell maturation, other signaling pathways may be …

… with 17β-estradiol (10 −9 M) or 5α-dihydrotestosterone (a non… by causing spermiation failure
and germ cell apoptosis [17,27]… in germ cells and Sertoli cells from control rats. Interestingly, …